report-generator Skill

--- name: report-generator description: | Generate professional drug discovery reports including target dossiers, competitive briefs, and Go/No-Go decision summaries. Use this skill when you need formatted reports for presentations, decision meetings, or documentation. Supports multiple output formats. Keywords: report, dossier, decision, go-no-go, brief, presentation category: Report Generation tags: [report, dossier, decision, go-no-go] version: 1.0.0 author: Drug Discovery Team dependencies: [] --- # Report Generator Skill Generate professional drug discovery intelligence reports. ## Quick Start ``` /dossier EGFR --format pdf /brief EGFR competitors --format ppt /gng project-KRAS --full /report --template competitor-brief Generate a Go/No-Go report for HER2 inhibitor project ``` ## What's Included | Report Type | Description | Use Case | |-------------|-------------|----------| | **Target Dossier** | Comprehensive target analysis | Target validation meetings | | **Competitor Brief** | Competitive intelligence summary | Portfolio reviews | | **Go/No-Go** | Decision support with scoring | Investment decisions | | **Weekly Update** | Weekly intelligence summary | Team updates | | **Project Overview** | Full project analysis | Stakeholder reports | ## Report Types ### 1. Target Dossier (`/dossier`) Comprehensive target analysis for validation decisions. **Sections:** - Executive Summary (1 page) - Target Overview - Druggability Assessment - Disease Associations - Competitive Landscape - Safety Assessment - Opportunities & Risks - Recommendations **Output:** PDF (10-15 pages) ``` /dossier EGFR /target-dossier KRAS G12C --format pdf Generate dossier for BRAF V600E ``` ### 2. Competitor Brief (`/brief`) Competitive intelligence summary for portfolio reviews. **Sections:** - Market Overview - Approved Products - Pipeline Analysis - Company Landscape - Key Differentiators - White Space **Output:** PPT (8-12 slides) ``` /brief EGFR inhibitors /competitor-brief GLP-1 agonists --format ppt Create competitor brief for obesity market ``` ### 3. Go/No-Go Analysis (`/gng`) Decision support with multi-dimensional scoring. **Scoring Dimensions:** | Dimension | Weight | Assessment Criteria | |-----------|--------|---------------------| | Scientific Rationale | 25% | Target validation, disease linkage strength | | Differentiation | 20% | Competitive advantage, novelty | | Feasibility | 20% | Technical feasibility, developability | | Commercial | 20% | Market size, unmet need, pricing | | IP/Safety | 15% | Patentability, safety risk | **Score Interpretation:** - **80-100**: Strong Go - Proceed with confidence - **60-79**: Go with conditions - Address specific concerns - **40-59**: Caution - Significant concerns, re-evaluate - **0-39**: No-Go - Do not proceed **Output:** PDF with scorecard (5-8 pages) ``` /gng project-EGFR-4thgen /go-no-go KRAS inhibitor --full Generate Go/No-Go analysis for ADC program ``` ### 4. Weekly Update (`/weekly`) Weekly intelligence summary for team alignment. **Sections:** - Key Developments - Literature Highlights - Pipeline Updates - Conference Abstracts - Deals & News **Output:** Email/Markdown (1-2 pages) ``` /weekly --targets EGFR,KRAS,HER2 /weekly-update --diseases NSCLC,CRC Generate weekly report for oncology portfolio ``` ### 5. Project Overview (`/report --full`) Complete analysis combining all above sections. **Output:** Full report (30-50 pages) ``` /report --full EGFR program /generate full project report for KRAS G12C ``` ## Output Formats | Format | Description | Use Case | |--------|-------------|----------| | **Markdown** | Default, fully formatted | Quick review, version control | | **PDF** | Professional report | Meetings, archives | | **PPT** | Slide deck | Presentations | | **One-pager** | Single page summary | Executive updates | ## Go/No-Go Scoring Example ```markdown # Go/No-Go Analysis: KRAS G12C Inhibitor Project ## Overall Score: 72/100 (Go with Conditions) ### Dimension Scores | Dimension | Score | Weight | Weighted | Status | |-----------|-------|--------|----------|--------| | Scientific Rationale | 85/100 | 25% | 21.25 | ✅ Strong | | Differentiation | 65/100 | 20% | 13.00 | ⚠️ Moderate | | Feasibility | 75/100 | 20% | 15.00 | ✅ Good | | Commercial | 80/100 | 20% | 16.00 | ✅ Strong | | IP/Safety | 50/100 | 15% | 7.50 | ⚠️ Concern | ### Detailed Assessment #### Scientific Rationale (85/100) ✅ **Strengths:** - KRAS G12C validated in NSCLC, CRC - Strong genetic association - Clear mechanism of action **Score:** 85/100 #### Differentiation (65/100) ⚠️ **Strengths:** - First-in-class opportunity - Novel covalent binding **Concerns:** - 4 competitors in Phase II/III - Amgen and Mirati ahead **Score:** 65/100 #### Feasibility (75/100) ✅ **Strengths:** - Proven chemistry platform - Clear PK/PD biomarkers **Concerns:** - Resistance mutations observed - Combination complexity **Score:** 75/100 #### Commercial (80/100) ✅ **Strengths:** - Large NSCLC market - Premium pricing potential - Expansion to CRC, pancreatic **Score:** 80/100 #### IP/Safety (50/100) ⚠️ **Concerns:** - Patent landscape crowded - Off-target toxicity risks - Sotorasib safety signals **Score:** 50/100 ### Conditions to Proceed 1. **IP:** Conduct FTO analysis, explore novel binding pocket 2. **Safety:** Early toxicity profiling, off-target screening 3. **Differentiation:** Focus on combination strategies, CNS penetration ### Recommendation **PROCEED with Conditions** - Strong scientific and commercial rationale, but address IP position and safety profile before major investment. ``` ## Examples ### Target Dossier ``` /dossier EGFR Generate a target dossier for HER2 /target-dossier KRAS --focus safety ``` ### Competitor Brief ``` /brief EGFR TKIs Create competitor brief for obesity drugs /competitor-brief GLP-1 --format ppt --include-privates ``` ### Go/No-Go ``` /gng my-project-name /go-no-go KRAS G12C --full Generate decision report for ADC platform ``` ### Weekly Update ``` /weekly /weekly-update --targets EGFR,KRAS --format email ``` ### Custom Report ``` /report --template custom --sections exec-sum,market,competition /generate report using template project-overview ``` ## Running Scripts ```bash # Generate dossier python scripts/generate_dossier.py EGFR --format pdf --output reports/ # Generate brief python scripts/generate_brief.py "EGFR inhibitors" --format ppt # Go/No-Go with custom weights python scripts/generate_gng.py project-name --weights science=30,diff=15 # Weekly report python scripts/weekly_report.py --targets EGFR,KRAS,HER2 --format email ``` ## Requirements For PDF/PPT generation: ```bash pip install weasyprint python-pptx jinja2 pandas ``` ## Additional Resources - [Template Reference](reference/templates.md) - [Customization Guide](reference/customization.md) - [Script Usage](reference/scripts.md) ## Best Practices 1. **Specify format**: Always include output format 2. **Use templates**: Reference existing templates for consistency 3. **Include context**: Add project-specific considerations 4. **Review scores**: Validate Go/No-Go assumptions 5. **Version control**: Track report iterations ## Report Templates Templates are in `templates/` directory: ``` templates/ ├── target-dossier.md # Target validation report ├── competitor-brief.md # Competitive intelligence ├── go-no-go.md # Decision support ├── weekly-update.md # Weekly intelligence └── project-overview.md # Full project analysis ``` ## Common Pitfalls | Pitfall | Solution | |---------|----------| | Missing context | Include project background | | Generic scores | Customize weights by project | | Outdated data | Always refresh data before report | | Too long | Use executive summary | | Wrong format | Verify format before generation |